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KMID : 0388220140210050257
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Journal of the Korean Rheumatism Association
2014 Volume.21 No. 5 p.257 ~ p.260
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A Case of Relapsing Granulomatosis with Polyangiitis Treated Successfully with Rituximab
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Han Ji-Won
Kang Kwi-Young
Ban Tae-Hyun
Jo Ik-Hyun
Park Sung-Hwan
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Abstract
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Granulomatosis with polyangiitis (GPA) is a rare anti-neutrophil cytoplasmic antibody associated with systemic disease characterized by granulomas and vasculitis affect-ing small and medium vessels. Neurological manifestations in GPA are less frequent than classical manifestations, such as lung and kidney involvement, and cranial nerve palsies are much rarer. Cyclophosphamide and glucocorti-coids have been conventionally administered as an initial induction immunosuppressive therapy for GPA. However, increasing evidence has demonstrated the efficacy and safety of rituximab, an anti-B cell monoclonal antibody, for the treatment of GPA. Herein, we describe a successful treatment of relapsing GPA with cranial nerve involve-ment using rituximab in a 56-year-old male patient who was previously
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KEYWORD
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Granulomatosis with polyangiitis, Cranial nerve, Rituximab
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